Technology Process of (4aR,5R,8aR)-5-Benzyloxymethyl-1,1,6-trimethyl-4-oxo-1,5,8,8a-tetrahydro-4H-naphthalene-4a-carboxylic acid methyl ester
There total 2 articles about (4aR,5R,8aR)-5-Benzyloxymethyl-1,1,6-trimethyl-4-oxo-1,5,8,8a-tetrahydro-4H-naphthalene-4a-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 83 percent / NaH / tetrahydrofuran / 8 h / Ambient temperature
2: 84 percent / FeCl3 / diethyl ether / 48 h / -20 °C
With
sodium hydride;
iron(III) chloride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(00)82438-7
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123502-37-4
(4aR,5R,8aR)-5-Benzyloxymethyl-4a-methoxymethoxymethyl-1,1,6-trimethyl-1,2,3,4,4a,5,8,8a-octahydro-naphthalene
- Guidance literature:
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Multi-step reaction with 6 steps
1: tris(triphenylphosphine)rhodium(I) chloride / benzene
2: n-Bu4NF / tetrahydrofuran
3: 72 percent / sodium bis(2-methoxyethoxy)aluminum hydride / diethyl ether; toluene / Ambient temperature
4: 72 percent / KH / 1,2-dimethoxy-ethane / -10 °C
5: NaH / 1,2-dimethoxy-ethane / Ambient temperature
6: tri-n-butyltin hydride, AIBN / toluene / Heating
With
2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; potassium hydride; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride;
Wilkinson's catalyst;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; toluene; benzene;
DOI:10.1016/S0040-4039(00)82438-7
