N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Base Information

Chemical Name:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide
CAS No.:1395964-56-3
Molecular Formula:C₂₅H₂₅F₃N₄O₃S
Molecular Weight:518.56
Hs Code.:

Synonyms:N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Suppliers and Price of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

There total 3 articles about N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₃F₃N₄O₅S

: 1395964-56-3
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Guidance literature:: C₃₀H₃₃F₃N₄O₅S; Acidic conditions;

With sodium carbonate; In ethyl acetate;

Reference yield:

: 1355011-26-5
methyl 6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxylate

: 1395964-56-3
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / Dichlorodifluoromethane / 0.67 h / 0 °C

2.1: lithium hydroxide / tetrahydrofuran / 2 h / 37 °C

2.2: pH 4

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h

4.1: Acidic conditions

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; Dichlorodifluoromethane; N,N-dimethyl-formamide;

Reference yield:

: 1355011-27-6
methyl 6-[2,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoropyridine-2-carboxylate

: 1395964-56-3
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(methylsulfonyl)phenyl)-5-fluoropicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran / 2 h / 37 °C

1.2: pH 4

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h

3.1: Acidic conditions

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;