6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Base Information

Chemical Name:6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS No.:869464-83-5
Molecular Formula:C₁₉H₁₄N₄O₂
Molecular Weight:330.346
Hs Code.:
European Community (EC) Number:857-754-6
DSSTox Substance ID:DTXSID601142728
Nikkaji Number:J2.663.958A
Wikidata:Q27461227
ChEMBL ID:CHEMBL1233436

Synonyms:6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid;869464-83-5;6-phenyl-1-(pyridin-4-ylmethyl)pyrazolo[3,4-b]pyridine-4-carboxylic acid;CHEMBL1233436;DTXSID601142728;HMS1784I07;AKOS001138934;EN300-14619;AB00741918-01;Q27461227;Z98637462;1-(4-Pyridylmethyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid;6-Phenyl-1-(4-pyridinylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid;6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylicacid;6-phenyl-1-[(pyridin-4-yl)methyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid;HTJ

Suppliers and Price of 6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:330.11167570
Heavy Atom Count:25
Complexity:462

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC3=C(C=NN3CC4=CC=NC=C4)C(=C2)C(=O)O

Technology Process of 6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

There total 6 articles about 6-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1426935-47-8
C₂₁H₁₈N₄O₂

: 869464-83-5
C₁₉H₁₄N₄O₂

Guidance literature:: C₂₁H₁₈N₄O₂; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; In water;
DOI:10.1021/jm301709s

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 869464-83-5
C₁₉H₁₄N₄O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / ethanol / 24 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: sodium butanolate / butan-1-ol / 120 °C

3.1: benzene / 15 h / 65 °C

4.1: acetic acid / 4 h / Reflux

5.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 2 h / 20 °C

5.2: 4 h / 100 °C

6.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

With hydrazine hydrate; acetic acid; triethylamine; sodium butanolate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; butan-1-ol; benzene; 5.2: |Suzuki Coupling;
DOI:10.1021/jm301709s

Reference yield:

: 329264-80-4
C₉H₁₀N₄

: 869464-83-5
C₁₉H₁₄N₄O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium butanolate / butan-1-ol / 120 °C

2.1: benzene / 15 h / 65 °C

3.1: acetic acid / 4 h / Reflux

4.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 2 h / 20 °C

4.2: 4 h / 100 °C

5.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

With acetic acid; triethylamine; sodium butanolate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; butan-1-ol; benzene; 4.2: |Suzuki Coupling;
DOI:10.1021/jm301709s