(Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene

Base Information

• Chemical Name: (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene
• CAS No.: 1003321-89-8
• Molecular Formula: C₁₄H₁₀BrF₃O₃S₂
• Molecular Weight: 427.263
• Mol file: 1003321-89-8.mol

Synonyms:(Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene

Chemical Property of (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene

There total 1 articles about (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Thien-3-ylboronic acid (6165-69-1) + 1,1-dibromo-3,3,3-trifluoro-2-tosyloxypropene (1003321-80-9) → (E)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene (1003321-98-9) + (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene (1003321-89-8)

Guidance literature:

With potassium phosphate; tri(m-tolyl)phosphine; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 80 ℃; for 24h;

DOI:10.1002/anie.200703759

Reference yield: 88.0%

4-(naphthalene-2-yl)phenylboronic acid pinacol ester (918655-03-5) + (Z)-1-bromo-3,3,3-trifluoro-1-(3-thienyl)-2-tosyloxypropene (1003321-89-8) → (E)-3,3,3-trifluoro-1-(2-naphthyl)-1-(3-thienyl)-2-tosyloxypropene (1003322-07-3)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h;

DOI:10.1002/anie.200703759

upstream raw materials:

Thien-3-ylboronic acid

1,1-dibromo-3,3,3-trifluoro-2-tosyloxypropene

Downstream raw materials:

(E)-3,3,3-trifluoro-1-(2-naphthyl)-1-(3-thienyl)-2-tosyloxypropene