(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt

Base Information

• Chemical Name: (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt
• CAS No.: 1351070-06-8
• Molecular Formula: C₁₂H₂₇N*C₂₁H₂₀N₅O₆PS
• Molecular Weight: 686.813

Synonyms:(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt

Chemical Property of (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt

Chemical Property:

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Technology Process of (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt

There total 6 articles about (R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tributyl-amine (102-82-9) + C21H20N5O6PS (1351184-81-0) → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt (1351070-06-8)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(S(P))-N6-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-97-0) → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt (1351070-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: ammonium fluoride / N,N-dimethyl-formamide / 120 h / 20 °C

3.1: N,N-dimethyl-formamide

With ammonium fluoride; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(R(P))-N6-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid → (R(P))-N6-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid tri-n-butylammonium salt (1351070-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium fluoride / N,N-dimethyl-formamide / 120 h / 20 °C

2: N,N-dimethyl-formamide

With ammonium fluoride; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.10.003

upstream raw materials:

(S_P)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate

(S(P))-N₆-benzyl-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine cyclic 3',5'-N-benzylphosphoramidate

tributyl-amine

C₂₁H₂₀N₅O₆PS

Downstream raw materials:

(R(P))-N₆-benzyl-8-(2-furyl)adenosine cyclic 3',5'-phosphorothioic acid sodium salt

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