benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

Base Information

Chemical Name:benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate
CAS No.:1357252-47-1
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

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Chemical Property of benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

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Technology Process of benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

There total 6 articles about benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357252-46-0
benzyl 3-[5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1357252-47-1
benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 55 ℃; for 1h; Inert atmosphere;

benzyl 3-[5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate; In N,N-dimethyl-formamide; at 0 - 32 ℃; for 17.5h;

With water; In N,N-dimethyl-formamide; at 25 - 32 ℃; for 1h;

Reference yield:

: 6282-07-1
3-chloro-propionic acid benzyl ester

: 1357252-47-1
benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 15 h / 25 - 85 °C / Inert atmosphere

2.1: trichlorophosphate / 1 h / 0 - 50 °C / Inert atmosphere

2.2: 3 h / 0 - 32 °C

2.3: pH 7

3.1: ammonium acetate / 5 h / 50 °C / Inert atmosphere

4.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 32 °C / Inert atmosphere

4.2: 1 h / 25 - 32 °C / pH 4.1

5.1: trichlorophosphate / 1 h / 0 - 55 °C / Inert atmosphere

5.2: 17.5 h / 0 - 32 °C

5.3: 1 h / 25 - 32 °C

With sodium tetrahydroborate; ethanol; ammonium acetate; triethylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1357252-44-8
benzyl 3-(5-formyl-2,3-dihydro-1H-indol-1-yl)propanoate

: 1357252-47-1
benzyl 3-[7-formyl-5-(2-nitropropyl)-2,3-dihydro-1H-indol-1-yl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / 5 h / 50 °C / Inert atmosphere

2.1: ethanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 32 °C / Inert atmosphere

2.2: 1 h / 25 - 32 °C / pH 4.1

3.1: trichlorophosphate / 1 h / 0 - 55 °C / Inert atmosphere

3.2: 17.5 h / 0 - 32 °C

3.3: 1 h / 25 - 32 °C

With sodium tetrahydroborate; ethanol; ammonium acetate; trichlorophosphate; In tetrahydrofuran;