N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

Base Information

Chemical Name:N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate
CAS No.:1178578-25-0
Molecular Formula:C₂HF₃O₂*C₁₇H₁₇F₅N₆O₃S
Molecular Weight:594.442
Hs Code.:

Synonyms:N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

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Chemical Property of N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

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Technology Process of N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

There total 10 articles about N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178581-70-8
6-Ethoxy-[1,2,4]triazolo[4,3-b]-pyridazin-3-ylamine

: 1178584-06-9
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]acetamide

: 76-05-1
trifluoroacetic acid

: 1178578-25-0
N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

Guidance literature:: 6-Ethoxy-[1,2,4]triazolo[4,3-b]-pyridazin-3-ylamine; N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]acetamide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1178578-25-0
N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / 75 °C / Inert atmosphere

2.1: thionyl chloride / 10 h / Inert atmosphere; Reflux

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

5.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.2: 5 h / 0 - 20 °C

6.3: Cooling with ice

7.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 5 h / 20 - 40 °C / Inert atmosphere

8.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; hydrogen; nitric acid; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 852469-45-5
3-nitro-5-(pentafluoro-λ⁶-sulfanyl)benzoic acid

: 1178578-25-0
N-[3-[2-(6-ethoxy-3-imino-[1,2,4]triazolo[4,3-b]pyridazin-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 10 h / Inert atmosphere; Reflux

2.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

4.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 5 h / 0 - 20 °C

5.3: Cooling with ice

6.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 5 h / 20 - 40 °C / Inert atmosphere

7.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; hydrogen; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;