(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

Base Information

Chemical Name:(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide
CAS No.:1221411-88-6
Molecular Formula:C₂₁H₂₈N₂O₂
Molecular Weight:340.466
Hs Code.:

Synonyms:(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

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Technology Process of (E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

There total 5 articles about (E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: (E)-methyl 3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)phenyl)acrylate

: 1221411-88-6
(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 4h;
DOI:10.1021/jm500872p

Reference yield:

: 17768-41-1
adamantylmethylamine

: 1221411-88-6
(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 2 h / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: hydroxylamine hydrochloride; sodium hydroxide / methanol; tetrahydrofuran; water / 4 h / 0 - 20 °C

With sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm500872p

Reference yield:

: 7560-50-1,71093-79-3,58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

: 1221411-88-6
(E)-3-(4-((((3r,5r,7r)-adamantan-1-ylmethyl)amino)methyl)-phenyl)-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 2 h / 20 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: hydroxylamine hydrochloride; sodium hydroxide / methanol; tetrahydrofuran; water / 4 h / 0 - 20 °C

With sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm500872p