{(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine

Base Information

• Chemical Name: {(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine
• CAS No.: 1002344-77-5
• Molecular Formula: C₂₁H₁₇F₅N₂O₂
• Molecular Weight: 424.37

Synonyms:{(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine

Chemical Property of {(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine

Chemical Property:

Purity/Quality:

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Technology Process of {(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine

There total 1 articles about {(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(3,5-difluoro-2-methoxyphenyl)methylene]-2-methylquinolin-5-amine (1002344-78-6) → {(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine (1002344-77-5)

Guidance literature:

1,1,1-trifluoro-2,3-epoxypropane; With n-butyllithium; In tetrahydrofuran; hexane; at -100 - -96 ℃; for 2.16667h;

[(3,5-difluoro-2-methoxyphenyl)methylene]-2-methylquinolin-5-amine; In tetrahydrofuran; hexane; at -100 - 0 ℃; for 4.5h;

Reference yield:

{(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine (1002344-77-5) → α-Bromomethyl-3,5-difluoro-2-methoxy-β-[(2-methylquinolin-5-yl)amino]-α-(trifluoromethyl)-benzeneethanol

Guidance literature:

With aluminum tri-bromide; In benzene; at 5 - 25 ℃; for 3h;

Reference yield:

{(3,5-difluoro-2-methoxyphenyl)[2-(trifluoromethyl)oxiranyl]methyl}-(2-methylquinolin-5-yl)-amine (1002344-77-5) → α-chloromethyl-3,5-difluoro-2-methoxy-β-[(2-methylquinolin-5-yl)-amino]-α-(trifluoromethyl)-benzeneethanol

Guidance literature:

With aluminum (III) chloride; In benzene; at 5 - 25 ℃; for 3h;

upstream raw materials:

[(3,5-difluoro-2-methoxyphenyl)methylene]-2-methylquinolin-5-amine

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