H-CYS(BZL)-AMC

Base Information

• Chemical Name: H-CYS(BZL)-AMC
• CAS No.: 80173-27-9
• Molecular Formula: C₂₀H₂₀N₂O₃S
• Molecular Weight: 368.456
• Mol file: 80173-27-9.mol

Synonyms:S-BENZYL-L-CYSTEINE 7-AMIDO-4-METHYLCOUMARIN;H-CYS(BZL)-AMC;CYSTEINE(BZL)-AMC;CYS(BZL)-7-AMIDO-4-METHYLCOUMARIN;7-benzylcysteinyl-4-methylcoumarinylamide

Chemical Property of H-CYS(BZL)-AMC

Chemical Property:

• Vapor Pressure: 3.04E-15mmHg at 25°C
• Boiling Point: 618.9°C at 760 mmHg
• PKA: 12.69±0.20(Predicted)
• Flash Point: 328.1°C
• PSA: 114.12000
• Density: 1.316g/cm³
• LogP: 4.65040
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

S-Benzyl-L-cysteine 7-Amido-4-methylcoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: S-Benzyl-L-cysteine 7-Amido-4-methylcoumarin is a sensitive fluorogenic substrate for serum cystyl amino-peptidase (oxytocinase).

Technology Process of H-CYS(BZL)-AMC

There total 3 articles about H-CYS(BZL)-AMC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-carbobenzoxy-S-benzyl-L-cysteine-4-methylcoumarinyl-7-amide (82437-49-8) → S-benzyl-L-cysteine-4-methylcoumarinyl-7-amide (82437-48-7,80173-27-9)

Guidance literature:

With hydrogen bromide; acetic acid; for 40h; Ambient temperature;

DOI:10.1248/cpb.30.1485

Reference yield:

benzyloxycarbonyl-S-benzylcysteine (3257-18-9) → S-benzyl-L-cysteine-4-methylcoumarinyl-7-amide (82437-48-7,80173-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, Et₃N / 1.) THF, -5 deg C, 10 min; 2.) THF-DMF, ice-bath, 1h: rt, overnight

2: 25percent HBr-AcOH / 40 h / Ambient temperature

With hydrogen bromide; acetic acid; triethylamine; isobutyl chloroformate;

DOI:10.1248/cpb.30.1485

Reference yield:

7-amino-4-methylcoumarin. (26093-31-2) → S-benzyl-L-cysteine-4-methylcoumarinyl-7-amide (82437-48-7,80173-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, Et₃N / 1.) THF, -5 deg C, 10 min; 2.) THF-DMF, ice-bath, 1h: rt, overnight

2: 25percent HBr-AcOH / 40 h / Ambient temperature

With hydrogen bromide; acetic acid; triethylamine; isobutyl chloroformate;

DOI:10.1248/cpb.30.1485

upstream raw materials:

N-carbobenzoxy-S-benzyl-L-cysteine-4-methylcoumarinyl-7-amide

benzyloxycarbonyl-S-benzylcysteine

7-amino-4-methylcoumarin.

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