6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

Base Information

Chemical Name:6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid
CAS No.:1440966-15-3
Molecular Formula:C₃₈H₄₂N₄O₁₄S₂
Molecular Weight:842.902
Hs Code.:

6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

Synonyms:6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

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Chemical Property of 6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

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Technology Process of 6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

There total 3 articles about 6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1440966-06-2
ethyl-6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoate

: 1440966-15-3
6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1038/aps.2012.151

Reference yield:

: C₃₇H₄₀N₄O₁₂S₂

: 1440966-15-3
6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

With boron tribromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1038/aps.2012.151

Reference yield:

: 1440966-05-1
ethyl-6-(N-(4-(7,8-dihydroxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoate

: 1440966-15-3
6-(N-(4-(7,8-bis(methoxymethoxy)-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrophenylsulfonamido)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1038/aps.2012.151