methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

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Chemical Name:methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate
CAS No.:1094568-61-2
Molecular Formula:C₂₈H₂₈F₂N₄O₃S
Molecular Weight:538.618
Hs Code.:

Synonyms:methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

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Chemical Property of methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

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Technology Process of methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

There total 1 articles about methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094568-60-1
methyl 3-{[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

: 74427-22-8
2,2-difluoroethyl triflate

: 1094568-61-2
methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

Guidance literature:: methyl 3-{[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

2,2-difluoroethyl triflate; In N,N-dimethyl-formamide; at 70 ℃; for 23h;

Reference yield:

: 1094568-61-2
methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

: 1094568-52-1
3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylic acid

Guidance literature:: methyl 3-{(2,2-difluoroethyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 20h;

With hydrogenchloride; In water;