6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

Base Information

Chemical Name:6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one
CAS No.:128317-29-3
Molecular Formula:C₁₅H₂₀N₂O₄
Molecular Weight:292.335
Hs Code.:

Synonyms:6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

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Chemical Property of 6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

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Technology Process of 6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

There total 4 articles about 6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 128317-15-7
7-(3,4-Dimethoxy-phenyl)-6-hydroxy-4-oxo-heptanoic acid

: 128317-29-3
6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With hydrazine hydrate; In ethanol; water; for 1h; Heating;
DOI:10.1002/jhet.5570270315

Reference yield:

: 93-15-2
1,2-dimethoxy-4-(2-propenyl)benzene

: 128317-29-3
6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: phenyl isocyanate, Et₃N / benzene / 1) room temperature, 2) 2 h, reflux

2: 90 percent / 0.5 N NaOH / methanol

3: 70 percent / H₂ / W-2 Raney nickel / methanol; acetic acid; H₂O / 5 h / 760 Torr / Ambient temperature

4: 75 percent / NH₂-NH₂ * H₂O / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; hydrogen; phenyl isocyanate; hydrazine hydrate; triethylamine; W-2 Raney nickel; In methanol; ethanol; water; acetic acid; benzene;
DOI:10.1002/jhet.5570270315

Reference yield:

: 128317-02-2
3-[5-(3,4-Dimethoxy-benzyl)-4,5-dihydro-isoxazol-3-yl]-propionic acid

: 128317-29-3
6-[3-(3,4-Dimethoxy-phenyl)-2-hydroxy-propyl]-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / H₂ / W-2 Raney nickel / methanol; acetic acid; H₂O / 5 h / 760 Torr / Ambient temperature

2: 75 percent / NH₂-NH₂ * H₂O / ethanol; H₂O / 1 h / Heating

With hydrogen; hydrazine hydrate; W-2 Raney nickel; In methanol; ethanol; water; acetic acid;
DOI:10.1002/jhet.5570270315