2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

Base Information

Chemical Name:2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid
CAS No.:347173-20-0
Molecular Formula:C₃₇H₃₈ClN₃O₅S
Molecular Weight:672.245
Hs Code.:

Synonyms:2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

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Chemical Property of 2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

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Technology Process of 2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

There total 11 articles about 2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 347165-36-0
ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)-1H-benzimidazole-5-carboxylate

: 347173-20-0
2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

2: aq. NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 1 h / Heating

3: aq. NaOH / ethanol; tetrahydrofuran / 1 h / Heating

With sodium hydroxide; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm060269e

Reference yield:

: 2-bromo-5-chlorosulfonylbenzoyl chloride

: 347173-20-0
2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran; H₂O / 1 h / 20 °C

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: CBr₄; PPh₃ / tetrahydrofuran / 1 h / 20 °C

5: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

6: aq. NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 1 h / Heating

7: aq. NaOH / ethanol; tetrahydrofuran / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 6: Suzuki coupling;
DOI:10.1021/jm060269e

Reference yield:

: 924867-87-8
methyl 2-bromo-5-(chlorosulfonyl)benzoate

: 347173-20-0
2-[4-(4-tert-butylsulfamoyl-4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran; H₂O / 1 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 0 °C

3: CBr₄; PPh₃ / tetrahydrofuran / 1 h / 20 °C

4: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

5: aq. NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 1 h / Heating

6: aq. NaOH / ethanol; tetrahydrofuran / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 5: Suzuki coupling;
DOI:10.1021/jm060269e