18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

Base Information

Chemical Name:18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester
CAS No.:497967-93-8
Molecular Formula:C₃₇H₆₀N₂O₁₇
Molecular Weight:804.887
Hs Code.:

18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

Synonyms:18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

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Chemical Property of 18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

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Technology Process of 18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

There total 6 articles about 18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 497967-90-5
18-Amino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

: 497967-82-5
18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid

: 497967-93-8
18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 120h;
DOI:10.1016/S0040-4020(02)01065-7

Reference yield:

: 497967-76-7
10,13,16,19,22,25,28-heptaoxa-7-aza-dispiro[5.1.18.2]octacosane

: 497967-93-8
18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: hydrochloric acid / H₂O / 5 h / 55 °C

2: 4.47 g / NaHCO₃ / H₂O; dioxane / 4 h / 0 - 20 °C

3: 70 percent / TEMPO; NaHCO₃; NaClO / H₂O; acetonitrile / 20 °C

4: 99 percent / diethyl ether; CH₂Cl₂ / 0.25 h

5: 98 percent / H₂ / 10 percent Pd/C / methanol

6: 62 percent / benzotriazol-1-yl-oxy-tripyrrolidinophosphonium PF₆^(1-); diisopropylethylamine / CH₂Cl₂ / 120 h / 20 °C

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(02)01065-7

Reference yield:

: 497967-79-0
(18-Hydroxymethyl-1,4,7,10,13,16-hexaoxa-cyclononadec-18-yl)-carbamic acid benzyl ester

: 497967-93-8
18-[(18-Benzyloxycarbonylamino-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carbonyl)-amino]-1,4,7,10,13,16-hexaoxa-cyclononadecane-18-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / TEMPO; NaHCO₃; NaClO / H₂O; acetonitrile / 20 °C

2: 99 percent / diethyl ether; CH₂Cl₂ / 0.25 h

3: 98 percent / H₂ / 10 percent Pd/C / methanol

4: 62 percent / benzotriazol-1-yl-oxy-tripyrrolidinophosphonium PF₆^(1-); diisopropylethylamine / CH₂Cl₂ / 120 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(02)01065-7