Technology Process of N-((2,2-dimethylcyclohexyl)methyl)-3-fluoro-N-methylaniline hydrochloride
There total 9 articles about N-((2,2-dimethylcyclohexyl)methyl)-3-fluoro-N-methylaniline hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium tetrahydroborate / methanol / -78 - -30 °C
2: thionyl chloride; pyridine / dichloromethane / 5 h / 0 - 20 °C
3: diisobutylaluminium hydride / dichloromethane; hexane / 1.5 h / -78 - 0 °C
4: palladium on activated charcoal; hydrogen / methanol / 20 °C
5: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C
6: methanol / 1 h / 20 °C
7: acetic acid; sodium cyanoborohydride / methanol / 20 °C
8: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
9: hydrogenchloride / diethyl ether / 2 h / 0 - 20 °C
With
pyridine; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; palladium on activated charcoal; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid;
In
methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid; sodium cyanoborohydride / methanol / 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3: hydrogenchloride / diethyl ether / 2 h / 0 - 20 °C
With
hydrogenchloride; sodium hydride; sodium cyanoborohydride; acetic acid;
In
methanol; diethyl ether; N,N-dimethyl-formamide;
