(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

Base Information

Chemical Name:(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole
CAS No.:174259-08-6
Molecular Formula:C₂₁H₂₀ClNO₂
Molecular Weight:353.848
Hs Code.:

Synonyms:(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

Suppliers and Price of (E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

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Technology Process of (E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

There total 7 articles about (E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3-[3-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-but-2-en-1-ol

: 174259-08-6
(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

Guidance literature:: With calcium carbonate; trichlorophosphate;

Reference yield: 86.0%

: 174259-07-5
(E)-3-[3-(5-methyl-2-phenyloxazol-4-ylmethoxy)phenyl]but-2-en-ol

: 174259-08-6
(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

Guidance literature:: With phosphorus pentachloride; calcium carbonate; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 27492-46-2
4,5-dimethyl-2-phenyl-oxazole 3-oxide

: 174259-08-6
(E)-4-[3-(3-chloro-1-methylpropenyl)phenoxymethyl]-5-methyl-2-phenyloxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: POCl₃ / CHCl₃ / 2.5 h / Heating

2.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

3.1: NaH / toluene / 1 h

3.2: toluene; tetrahydrofuran / 48 h

4.1: DIBAL / diethyl ether / 0.5 h / -78 °C

5.1: 86 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

With phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; trichlorophosphate; In diethyl ether; chloroform; N,N-dimethyl-formamide; toluene; 1.1: Chlorination / 2.1: Alkylation / 3.1: Metallation / 3.2: Condensation / 4.1: Reduction / 5.1: Chlorination;
DOI:10.1021/jm990476x