6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline

Base Information

• Chemical Name: 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline
• CAS No.: 1416261-24-9
• Molecular Formula: C₂₃H₁₃F₃N₆
• Molecular Weight: 430.392

Synonyms:6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline

Chemical Property of 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline

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Technology Process of 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline

There total 3 articles about 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

9-fluoro-6-(prop-2-yn-1-yl)-6H-indolo[2,3-b]quinoxaline (1416261-08-9) + 1-azido-2,4-difluorobenzene (91229-55-9) → 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline (1416261-24-9)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1007/s00044-012-0373-7

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline (1416261-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / Sealed tube; Microwave irradiation

2: potassium carbonate / acetone / Reflux

3: copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; acetic acid; In tetrahydrofuran; acetone;

DOI:10.1007/s00044-012-0373-7

Reference yield:

1,2-diamino-benzene (95-54-5) → 6-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-9-fluoro-6H-indolo[2,3-b]quinoxaline (1416261-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / Sealed tube; Microwave irradiation

2: potassium carbonate / acetone / Reflux

3: copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; acetic acid; In tetrahydrofuran; acetone;

DOI:10.1007/s00044-012-0373-7

upstream raw materials:

5-fluoro-1H-indole-2,3-dione

1,2-diamino-benzene

9-fluoro-6-(prop-2-yn-1-yl)-6H-indolo[2,3-b]quinoxaline

1-azido-2,4-difluorobenzene

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