2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Base Information

Chemical Name:2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide
CAS No.:1059618-10-8
Molecular Formula:C₁₅H₁₀BrClFN₃O₂
Molecular Weight:398.619
Hs Code.:

Synonyms:2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Suppliers and Price of 2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

There total 8 articles about 2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 770719-12-5
[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

: 1059618-10-8
2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Guidance literature:: With hydrazine; In ethanol;
DOI:10.1016/j.bmcl.2008.06.080

Reference yield:

: 6575-00-4
3,5-dichlorobenzonitrile

: 1059618-10-8
2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 0 °C

1.2: Cooling with ice

2.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

2.2: Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

4.3: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

7.1: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.25 h / 50 °C

8.1: hydrazine / ethanol / 2 h / Reflux

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper(I) bromide; lithium iodide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 473923-97-6
3-chloro-5-hydroxybenzonitrile

: 1059618-10-8
2-{4-bromo-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 4 h / 0 - 20 °C

2.3: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

3.2: 0 °C

4.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

5.1: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.25 h / 50 °C

6.1: hydrazine / ethanol / 2 h / Reflux

With tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper(I) bromide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; mineral oil;