tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate
CAS No.:1236007-18-3
Molecular Formula:C₉H₁₇NO₂S
Molecular Weight:203.305
Hs Code.:

Synonyms:tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Suppliers and Price of tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
1-Boc-3-(mercaptomethyl)-azetidine 97%
0.25g
$ 381.33

ACHEMBLOCK
1-Boc-3-(mercaptomethyl)-azetidine 95%
250MG
$ 470.00

ACHEMBLOCK
1-Boc-3-(mercaptomethyl)-azetidine 95%
100MG
$ 245.00

Total 3 raw suppliers

Chemical Property of tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-3-(mercaptomethyl)-azetidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

There total 8 articles about tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1236007-16-1
tert-butyl 3-(acetylsulfanylmethyl)azetidine-1-carboxylate

: 1236007-18-3
tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 16h;

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 1236007-18-3
tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate; methyl-triphenylphosphonium iodide / diethyl ether / 2 h / 35 °C

2.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

5.1: sodium methylate / methanol / 0.25 h / Inert atmosphere

With borane-THF; potassium tert-butylate; sodium methylate; methyl-triphenylphosphonium iodide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 934664-41-2
3-methylene-azetidine-1-carboxylic acid tert-butyl ester

: 1236007-18-3
tert-butyl 3-(mercaptomethyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

4.1: sodium methylate / methanol / 0.25 h / Inert atmosphere

With borane-THF; sodium methylate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;