(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

Base Information

Chemical Name:(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide
CAS No.:107994-39-8
Molecular Formula:C₂₉H₃₅N₅O₄S*HI
Molecular Weight:677.606
Hs Code.:

Synonyms:(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

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Chemical Property of (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

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Technology Process of (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

There total 7 articles about (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 107994-31-0
4-(2-Butylcarbamoyl-2-{[(S)-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-thiobenzimidic acid methyl ester; hydriodide

: 107994-39-8
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

Guidance literature:: With ammonium acetate; In methanol; at 60 ℃; for 3h;

Reference yield:

: 91872-30-9
N-(2-naphthylsulfonyl)-(S)-proline

: 107994-39-8
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

Guidance literature:: Multi-step reaction with 7 steps

1: DCC / pyridine / 2 h, 0 deg C; 12 h, room temp.

2: TEA / pyridine / 2 h

3: DCC / ethyl acetate; pyridine / 24 h / Ambient temperature

4: ethyl acetate; pyridine / 4 h / Ambient temperature

5: 95 percent / H₂S / pyridine; triethylamine / 72 h / Ambient temperature

6: 80 percent / acetone / 0.25 h / Heating

7: 75 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; In pyridine; methanol; ethyl acetate; triethylamine; acetone;

Reference yield:

: (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid 4-nitro-phenyl ester

: 107994-39-8
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid [1-butylcarbamoyl-2-(4-carbamimidoyl-phenyl)-ethyl]-amide; hydriodide

Guidance literature:: Multi-step reaction with 6 steps

1: TEA / pyridine / 2 h

2: DCC / ethyl acetate; pyridine / 24 h / Ambient temperature

3: ethyl acetate; pyridine / 4 h / Ambient temperature

4: 95 percent / H₂S / pyridine; triethylamine / 72 h / Ambient temperature

5: 80 percent / acetone / 0.25 h / Heating

6: 75 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; In pyridine; methanol; ethyl acetate; triethylamine; acetone;