(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

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Chemical Name:(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide
CAS No.:360558-50-5
Molecular Formula:C₃₀H₄₁FN₄O₄
Molecular Weight:540.678
Hs Code.:

Synonyms:(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

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Chemical Property of (S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

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Technology Process of (S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

There total 7 articles about (S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 360558-40-3
(2R,3S)-3-Benzyl-4-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-fluoro-4-oxo-butyric acid

: 360558-50-5
(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / benzene; methanol; hexane / 0.5 h / 23 °C

2: 89 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 23 °C

3: NaBH₄ / ethanol / 25 h / -70 - 0 °C

4: 818 mg / t-BuOK / tetrahydrofuran / 0.75 h / 0 °C

5: propan-2-ol / 11 h / Heating

6: 198.0 mg / aq. HCl / 0 - 23 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; In tetrahydrofuran; methanol; ethanol; hexane; isopropyl alcohol; benzene;
DOI:10.1021/ja010113y

Reference yield:

: 360558-41-4
(2R,3S)-3-Benzyl-4-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-fluoro-4-oxo-butyric acid methyl ester

: 360558-50-5
(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 23 °C

2: NaBH₄ / ethanol / 25 h / -70 - 0 °C

3: 818 mg / t-BuOK / tetrahydrofuran / 0.75 h / 0 °C

4: propan-2-ol / 11 h / Heating

5: 198.0 mg / aq. HCl / 0 - 23 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; In tetrahydrofuran; ethanol; hexane; isopropyl alcohol;
DOI:10.1021/ja010113y

Reference yield:

: 360558-43-6
(2S,3R)-2-Benzyl-5-chloro-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-3-fluoro-pentane-1,4-dione

: 360558-50-5
(S)-1-[(2R,3R,4S)-3-Fluoro-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / ethanol / 25 h / -70 - 0 °C

2: 818 mg / t-BuOK / tetrahydrofuran / 0.75 h / 0 °C

3: propan-2-ol / 11 h / Heating

4: 198.0 mg / aq. HCl / 0 - 23 °C

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; In tetrahydrofuran; ethanol; isopropyl alcohol;
DOI:10.1021/ja010113y