Technology Process of Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
There total 7 articles about Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester which
guide to synthetic route it.
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synthetic route:
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![Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester](/Databaselist/images/loading.webp)
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1027383-25-0
Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
- Guidance literature:
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With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
for 3h;
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1027383-25-0
Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
- Guidance literature:
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Multi-step reaction with 6 steps
1: 98 percent / imidazole / dimethylformamide / 20 h
2: 67 percent / diisobutylaluminum hydride / toluene; hexane / 0.33 h / -78 °C
3: PPTS / 0.5 h / Ambient temperature
4: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature
5: 83 percent / pyridine / acetone / 3 h / Ambient temperature
6: methanesulfonyl chloride, Et3N / CH2Cl2 / 3 h
With
pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
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1027383-25-0
Carbonic acid benzyl ester 4-((5R,5aR,6R,8aR,9S)-9-chloro-6-methoxy-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 83 percent / pyridine / acetone / 3 h / Ambient temperature
2: methanesulfonyl chloride, Et3N / CH2Cl2 / 3 h
With
pyridine; methanesulfonyl chloride; triethylamine;
In
dichloromethane; acetone;
