Technology Process of N-{3,5-bis[((2)H3)methyloxy]phenyl}-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]((2)H4)ethane-1,2-diamine
There total 9 articles about N-{3,5-bis[((2)H3)methyloxy]phenyl}-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]((2)H4)ethane-1,2-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
acetonitrile;
at 140 ℃;
for 1h;
sealed vessel;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / acetonitrile / 18 h / 80 °C
2.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 96 h / 100 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C
3.2: 4 h / 5 - 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
4.2: Cooling with ice
5.1: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere
6.1: acetonitrile / 1 h / 140 °C / sealed vessel; microwave irradiation
With
tetrabutyl ammonium fluoride; sodium hydride; caesium carbonate; triethylamine; sodium t-butanolate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 96 h / 100 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C
2.2: 4 h / 5 - 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
3.2: Cooling with ice
4.1: triethylamine / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere
5.1: acetonitrile / 1 h / 140 °C / sealed vessel; microwave irradiation
With
tetrabutyl ammonium fluoride; sodium hydride; triethylamine; sodium t-butanolate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
