5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

Base Information

Chemical Name:5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde
CAS No.:1610373-25-5
Molecular Formula:C₂₁H₂₉NO₅SSi
Molecular Weight:435.616
Hs Code.:

Synonyms:5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

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Chemical Property of 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

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Technology Process of 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

There total 5 articles about 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1610372-27-4
6-bromo-5-(2-((tert-butyldimethylsilyl)-oxy)ethoxy)picolinaldehyde

: (2-(methylsulfonyl)-phenyl)boronic acid

: 1610373-25-5
5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610373-25-5
5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 20 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610373-25-5
5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-methanesulfonyl-phenyl)-pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 20 h / 100 °C / Inert atmosphere

With ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; sodium carbonate; potassium carbonate; potassium hydroxide; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;