N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide

Base Information

Chemical Name:N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide
CAS No.:191594-64-6
Molecular Formula:C39H53N5O7
Molecular Weight:703.8674
Hs Code.:
Mol file:191594-64-6.mol

N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide

Synonyms:

Suppliers and Price of N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide

Chemical Property:

Density:1.164g/cm³

Purity/Quality:: >98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide

There total 8 articles about N-(Methoxycarbonyl)-L-tert-leucine N2-(biphenyl-4-ylmethyl)-N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(methoxycarbonyl)-(L)-tert-leucine

: 478547-15-8
1-(4-biphenylyl)-5(S)-2,5-diamino-4(S)-hydroxy-6-phenyl-2-azahexane hydrochloride

: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 191594-64-6
CGP 75355

Guidance literature:: With 4-methyl-morpholine; In water; N,N-dimethyl-formamide;

Reference yield:

: 3218-36-8
4-Phenylbenzaldehyde

: 191594-64-6
CGP 75355

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / 4 h / Heating

2: 62 percent / H₂ / 10percent Pd/C / methanol

3: 86 percent / propan-2-ol / 16 h / Heating

4: 100 percent / 4N HCl / dioxane / 3 h / Ambient temperature

5: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, overnight

With hydrogenchloride; hydrogen; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c

Reference yield:

: N'-[1-Biphenyl-4-yl-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

: 191594-64-6
CGP 75355

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / H₂ / 10percent Pd/C / methanol

2: 86 percent / propan-2-ol / 16 h / Heating

3: 100 percent / 4N HCl / dioxane / 3 h / Ambient temperature

4: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, overnight

With hydrogenchloride; hydrogen; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; isopropyl alcohol;
DOI:10.1021/jm970873c