4-amino-7-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-amino-7-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• CAS No.: 115044-83-2
• Molecular Formula: C₁₂H₁₁N₅O₂
• Molecular Weight: 257.252

Synonyms:7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,4-amino-7-[2,5-dihydro-5-(hydroxymethyl)-2-furanyl]-, (2R-cis)-

Chemical Property of 4-amino-7-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

• Vapor Pressure: 1.61E-15mmHg at 25°C
• Boiling Point: 605.6°C at 760 mmHg
• Flash Point: 320.1°C
• Density: 1.62g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-7-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 1 articles about 4-amino-7-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Vengicide (606-58-6) → 4-Amino-5-cyano-7-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)pyrrolo<2,3-d>pyrimidine (115044-83-2)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00129a034

Reference yield: 89.0%

4-Amino-5-cyano-7-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)pyrrolo<2,3-d>pyrimidine (115044-83-2) → 2',3'-dideoxytoyocamycin (115044-81-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 19 - 22 ℃; for 5h; under 517.1 Torr;

DOI:10.1021/jo00129a034

upstream raw materials:

Vengicide

Downstream raw materials:

2',3'-dideoxytoyocamycin

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