10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Base Information

Chemical Name:10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane
CAS No.:75209-75-5
Molecular Formula:C₁₉H₂₇NO₃
Molecular Weight:317.428
Hs Code.:

Synonyms:10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Suppliers and Price of 10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

There total 11 articles about 10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

: 108-24-7
acetic anhydride

: 75209-63-1
10-endo-amino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

: 75209-75-5
10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1248/cpb.28.1022

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 75209-75-5
10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Mg / 1.) THF, 2.) THF, room temp., 30 min, 50-55 deg C, 1 h

2: oxalic acid / toluene / 16 h / Heating

3: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

4: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

5: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

6: 78 percent / benzene / 20 h / Heating

7: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

8: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

9: 97.7 percent / 5percent NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; magnesium; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1248/cpb.28.1022

Reference yield:

: 2082-28-2
1-(m-methoxyphenyl)cycloheptanol

: 75209-75-5
10-endo-acetamino-9-endo-hydroxy-1-(m-methoxyphenyl)bicyclo<4.3.1>decane

Guidance literature:: Multi-step reaction with 8 steps

1: oxalic acid / toluene / 16 h / Heating

2: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

3: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

4: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

5: 78 percent / benzene / 20 h / Heating

6: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

7: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

8: 97.7 percent / 5percent NaHCO₃ / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1248/cpb.28.1022