2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

Base Information

Chemical Name:2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone
CAS No.:361569-01-9
Molecular Formula:C₁₈H₂₅Cl₂N₃O
Molecular Weight:370.322
Hs Code.:

Synonyms:2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

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Chemical Property of 2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

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Technology Process of 2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

There total 6 articles about 2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350228-91-0
(+)-tert-butyl (R)-4-[2-(3,4-dichlorophenyl)acetyl]-3-[(S)-1-(pyrrolidin-1-yl)ethyl]piperazine-1-carboxylate

: 361569-01-9
2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0223-5234(00)01208-3

Reference yield:

: 249611-19-6
(3R)-(-)-tert-Butyl 4-benzyl-3-[(1R)-1-hydroxyethyl]piperazine-1-carboxylate

: 361569-01-9
2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / N-methylmorpholine N-oxide; tetrapropylammonium perrutenate; molecular sieves 4 Angstroem / CH₂Cl₂ / 16 h / 20 °C

2.1: Ti(OiPr)4 / CH₂Cl₂ / 1.5 h / 20 °C

2.2: 62 percent / NaBH₃CN; molecular sieves 3 Angstroem / methanol; CH₂Cl₂ / 40 h / 20 °C

3.1: 643 mg / H₂ / 10percent Pd/C / methanol / 9 h / 20 °C / 975.1 Torr

4.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 2 h / 20 °C

4.2: 73 percent / CH₂Cl₂ / 24 h / 20 °C

5.1: 138 mg / CF₃CO₂H / CH₂Cl₂ / 10 h / 20 °C

With titanium(IV) isopropylate; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide; 1,1'-carbonyldiimidazole; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm0108395

Reference yield:

: 350228-88-5
(+)-tert-butyl (R)-3-acetyl-4-benzylpiperazine-1-carboxylate

: 361569-01-9
2-(3,4-Dichloro-phenyl)-1-[(R)-2-((S)-1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ti(OiPr)4 / CH₂Cl₂ / 1.5 h / 20 °C

1.2: 62 percent / NaBH₃CN; molecular sieves 3 Angstroem / methanol; CH₂Cl₂ / 40 h / 20 °C

2.1: 643 mg / H₂ / 10percent Pd/C / methanol / 9 h / 20 °C / 975.1 Torr

3.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 2 h / 20 °C

3.2: 73 percent / CH₂Cl₂ / 24 h / 20 °C

4.1: 138 mg / CF₃CO₂H / CH₂Cl₂ / 10 h / 20 °C

With titanium(IV) isopropylate; hydrogen; 1,1'-carbonyldiimidazole; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm0108395