(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

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Chemical Name:(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde
CAS No.:116391-23-2
Molecular Formula:C₂₂H₃₂O₂
Molecular Weight:328.495
Hs Code.:

Synonyms:(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

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Chemical Property of (S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

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Technology Process of (S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

There total 8 articles about (S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 114694-12-1
(5Z,7E)-(1S,3R,20S)-1,3-bis<(tert-butyldimethylsilyl)oxy>-9,10-seco-22,23-dinor-5,7,10(19)-cholatrien-24-ol

: 116391-23-2
(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

Guidance literature:: With oxalyl dichloride; TEA; dimethyl sulfoxide; In dichloromethane; at -61 ℃;
DOI:10.1016/S0040-4039(00)61826-9

Reference yield: 29.0%

: 97903-24-7
(5Z,7E)-(3S,20S)-3-hydroxy-9,10-seco-5,7,10⁽¹⁹⁾pregnatriene-20-carboxylic acid methyl ester

: 116391-23-2
(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

: 87407-53-2,116499-21-9
22-hydroxyhomopregnacalciferol

Guidance literature:: With diisobutylaluminium hydride;
DOI:10.1016/S0040-4039(00)61826-9

Reference yield:

: 99518-39-5
3β-hydroxy-22,23-dinor-5,7-choladienic acid methyl ester

: 116391-23-2
(S)-2-{(1R,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) UV irradiation, benzene-ethyl ether; 2.) isomerisation

2: 54 percent / DIBAL

With diisobutylaluminium hydride;
DOI:10.1016/S0040-4039(00)61826-9