2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Base Information

• Chemical Name: 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate
• CAS No.: 143344-24-5
• Molecular Formula: C₆₆H₁₀₃N₄O₁₅PSi₅
• Molecular Weight: 1363.96

Synonyms:2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Chemical Property of 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Chemical Property:

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Technology Process of 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

There total 1 articles about 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-[(2R,3R,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-3-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoyl]-1H-pyrimidine-2,4-dione + triethylammonium salt of 2',5'-bis-O-(tert-butyldimethylsilyl)-uridine 5'-hydrogenphosphonate (143294-18-2) → 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate (143294-25-1) + 2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate (143344-24-5)

Guidance literature:

With pivaloyl chloride; In pyridine;

DOI:10.1021/jo00049a022

Reference yield:

2',5'-bis-O-(tert-butyldimethylsilyl)uridin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate (143344-24-5) → C66H102N4O15PSSi5(1-) (143294-29-5)

Guidance literature:

With sulfur; In pyridine; for 3h;

DOI:10.1021/jo00049a022

upstream raw materials:

triethylammonium salt of 2',5'-bis-O-(tert-butyldimethylsilyl)-uridine 5'-hydrogenphosphonate

Downstream raw materials:

C₆₆H₁₀₂N₄O₁₅PSSi₅^(1-)

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