C₂₅H₂₇N₃O₄S

Base Information

• Chemical Name: C₂₅H₂₇N₃O₄S
• CAS No.: 1418120-86-1
• Molecular Formula: C₂₅H₂₇N₃O₄S
• Molecular Weight: 465.573
• Mol file: 1418120-86-1.mol

Synonyms:C₂₅H₂₇N₃O₄S

Chemical Property of C₂₅H₂₇N₃O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₇N₃O₄S

There total 12 articles about C₂₅H₂₇N₃O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(2S,4R)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide (1448189-45-4) + 3-ethoxybenzoic acid (621-51-2) → C25H27N3O4S (1418120-86-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; for 18h;

DOI:10.1002/anie.201206231

Reference yield:

2-(trimethylsilyl)ethyl 4-(4-methylthiazol-5-yl)benzylcarbamate (1448189-29-4) → C25H27N3O4S (1418120-86-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / acetonitrile / 24 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 15 h

3: hydrogenchloride / 1,4-dioxane / 1 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 18 h

With hydrogenchloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201206231

Reference yield:

2-(trimethylsilyl)ethyl 4-bromobenzylcarbamate (1448189-28-3) → C25H27N3O4S (1418120-86-1)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrabutyl-ammonium chloride; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 0.13 h / 170 °C / Microwave irradiation

2: tetrabutyl ammonium fluoride / acetonitrile / 24 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 15 h

4: hydrogenchloride / 1,4-dioxane / 1 h

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 18 h

With hydrogenchloride; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; tetrabutyl ammonium fluoride; tetrabutyl-ammonium chloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201206231

upstream raw materials:

(2S,4R)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

3-ethoxybenzoic acid

tert‐butyl (2S,4R)‐4‐hydroxy‐2‐({[4‐(4‐methyl‐1,3‐thiazol‐5‐yl)phenyl]methyl}carbamoyl)pyrrolidine‐1‐carboxylate

2-(trimethylsilyl)ethyl 4-bromobenzylcarbamate