ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

Base Information

Chemical Name:ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate
CAS No.:39677-42-4
Molecular Formula:C₉H₁₂N₂O₃S₂
Molecular Weight:260.338
Hs Code.:
Mol file:39677-42-4.mol

Synonyms:ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

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Chemical Property of ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

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Technology Process of ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

There total 4 articles about ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 116170-90-2
3-amino-4-cyano-5-(methylthio)thiophene-2-carboxylic acid ethyl ester

: 39677-42-4
ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

Guidance literature:: With sulfuric acid; at 20 ℃; for 5h;
DOI:10.1039/c7ob01923h

Reference yield:

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 39677-42-4
ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium sulfide nonahydrate / N,N-dimethyl-formamide / 1.25 h / Heating

1.2: 1.5 h / Heating

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Heating

3.1: sulfuric acid; water / 20 °C

With sodium sulfide nonahydrate; sulfuric acid; water; potassium carbonate; In N,N-dimethyl-formamide; 2.1: |Dieckmann Condensation;
DOI:10.1080/17415993.2016.1156117

Reference yield:

: C₉H₁₀N₂O₂S₂

: 39677-42-4
ethyl 3-amino-4-carbamoyl-5-(methylthio)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Heating

2: sulfuric acid; water / 20 °C

With sulfuric acid; water; potassium carbonate; In N,N-dimethyl-formamide; 1: |Dieckmann Condensation;
DOI:10.1080/17415993.2016.1156117