(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester
CAS No.:1272654-95-1
Molecular Formula:C₁₅H₂₄N₂O₇
Molecular Weight:344.365
Hs Code.:

Synonyms:(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

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Chemical Property of (S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

There total 1 articles about (S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1272654-95-1
(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; triethylamine / dichloromethane / 5 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: toluene-4-sulfonic acid / toluene / 20 h / 110 °C / Dean-Stark

With Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; In dichloromethane; toluene;

Reference yield:

: 1272654-95-1
(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

: 1256390-26-7
methyl ((S)-1-((S)-8-(5-(4-bromophenyl)-1H-imidazol-2-yl)-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tert-butyl alcohol / 2 h / 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3: ammonium acetate / 1,4-dioxane / 110 °C / Sealed tube

With ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1272654-95-1
(S)-7-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-1,4-dioxa-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

: 1399843-64-1
methyl ((S)-3-methyl-1-oxo-1-((S)-8-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / tert-butyl alcohol / 2 h / 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3: ammonium acetate / 1,4-dioxane / 110 °C / Sealed tube

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere; Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; potassium acetate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;