Technology Process of (2S,4R,6S)-2-(3',4'-hydroxyphenyl)-4-hydroxy-6-pentyltetrahydropyran
There total 4 articles about (2S,4R,6S)-2-(3',4'-hydroxyphenyl)-4-hydroxy-6-pentyltetrahydropyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 4h;
Heating;
DOI:10.1002/hlca.19970800209
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 1h;
DOI:10.1021/ol020127o
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (-)-diisopinocampheylchloroborane / tetrahydrofuran / 2 h / -78 - 20 °C
1.2: tetrahydrofuran / 2 h / -78 - 20 °C
1.3: sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 0.17 h / 20 °C
2.1: trimethylsilyl acetate; boron trifluoride etherate / cyclohexane / 2 h
3.1: 68 percent / potassium carbonate / methanol / 1 h / 20 °C
With
trimethylsilyl acetate; boron trifluoride diethyl etherate; potassium carbonate; (-)-diisopinocamphenylborane chloride;
In
tetrahydrofuran; methanol; cyclohexane;
2.1: Prins cyclization;
DOI:10.1021/ol020127o
