(E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

Base Information

Chemical Name:(E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one
CAS No.:1426076-52-9
Molecular Formula:C₃₀H₃₅F₃O₃
Molecular Weight:500.601
Hs Code.:

Synonyms:(E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

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Chemical Property of (E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

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Technology Process of (E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

There total 2 articles about (E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1778-02-5
Pregnenolone acetate

: 126202-23-1
2,3,5-trifluorobenzaldehyde

: 1426076-52-9
(E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

Guidance literature:: With 10% I₂ in Al₂O₃; In neat (no solvent); for 0.1h; Microwave irradiation;
DOI:10.1016/j.steroids.2012.12.003

Reference yield:

: 979-02-2
16-dehydropregnenolone acetate

: 1426076-52-9
(E)-1-[(3β)-3-(acetyloxy)-androst-5-en-17-yl]-3-(2,3,5-trifluorophenyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 3.5 h / 2327.23 Torr

2: 10% I₂ in Al₂O₃ / neat (no solvent) / 0.1 h / Microwave irradiation

With palladium 10% on activated carbon; 10% I₂ in Al₂O₃; hydrogen; In ethanol; 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.steroids.2012.12.003