1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Base Information

Chemical Name:1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
CAS No.:1430751-87-3
Molecular Formula:C₂₄H₃₂BClN₂O₂
Molecular Weight:426.794
Hs Code.:

Synonyms:1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

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Chemical Property of 1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

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Technology Process of 1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

There total 4 articles about 1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1228780-51-5
(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol

: 1430751-87-3
1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: With cyanomethylenetributyl-phosphorane; In toluene; at 20 ℃; for 16h;

Reference yield:

: 32767-46-7
methyl 4,4-dimethyl-2-oxocyclohexancarboxylate

: 1430751-87-3
1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dichloromethane / 0.5 h / 0 °C

1.2: 24 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane; methanol / 24 h / 70 °C

3.1: methanol; lithium aluminium tetrahydride / diethyl ether / 24 h / 20 °C

4.1: cyanomethylenetributyl-phosphorane / toluene / 16 h / 20 °C

With methanol; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; cesium fluoride; cyanomethylenetributyl-phosphorane; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; toluene; 2.1: |Suzuki Coupling;

Reference yield:

: 1228780-46-8
methyl 4,4-dimethyl-2-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene-1-carboxylate

: 1430751-87-3
1-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane; methanol / 24 h / 70 °C

2: methanol; lithium aluminium tetrahydride / diethyl ether / 24 h / 20 °C

3: cyanomethylenetributyl-phosphorane / toluene / 16 h / 20 °C

With methanol; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; cyanomethylenetributyl-phosphorane; In methanol; 1,2-dimethoxyethane; diethyl ether; toluene; 1: |Suzuki Coupling;