(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

Base Information

Chemical Name:(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine
CAS No.:225089-43-0
Molecular Formula:C₁₇H₂₃NO₃S
Molecular Weight:321.441
Hs Code.:

Synonyms:(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

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Chemical Property of (2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

Chemical Property:

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Technology Process of (2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

There total 6 articles about (2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 225089-42-9
methyl (2S,6R)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

: 225089-43-0
(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1016/0040-4039(96)00990-2

Reference yield:

: 180406-57-9
N-p-tolylsulfonyl-9-azabicyclo<3.3.1>nonan-3-one

: 225089-43-0
(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / (R)-<2-(4-methylpiperazinyl)-1-phenylethyl>(2,2-dimethylpropyl)amine, n-BuLi, hexamethylphosphortriamide / tetrahydrofuran; hexane / 1.) -100 deg C to room temperature, 1 h, 2.) -100 deg C, 40 min

2: 1.) Et₂Zn, 2.) n-Bu₄NF / 1.) CH₂Cl₂, hexane, room temperature, 1 h, 2.) THF, room temperature, 20 min

3: phenyliodine bistrifluoroacetate, trifluoromethanesulfonic acid / 0.08 h / Ambient temperature

4: DIBAL / CH₂Cl₂; hexane / 0.17 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; diethylzinc; diisobutylaluminium hydride; (R)-N-(2,2-dimethylpropyl)-1-phenyl-2-(4-methylpiperazinyl)ethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(99)00073-3

Reference yield:

: 225089-40-7
(1S,2S,3R,4R,6R)-4-hydroxy-3-methyl-N-(p-tolylsulfonyl)-10-azatricyclo<4.3.1.0^2,4>decane

: 225089-43-0
(2S,6R)-6-formylmethyl-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: phenyliodine bistrifluoroacetate, trifluoromethanesulfonic acid / 0.08 h / Ambient temperature

2: DIBAL / CH₂Cl₂; hexane / 0.17 h / -78 °C

With trifluorormethanesulfonic acid; diisobutylaluminium hydride; bis-[(trifluoroacetoxy)iodo]benzene; In hexane; dichloromethane;
DOI:10.1016/S0040-4020(99)00073-3