3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Base Information

Chemical Name:3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one
CAS No.:319425-62-2
Molecular Formula:C₁₈H₁₈N₂O₅
Molecular Weight:342.351
Hs Code.:

Synonyms:3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Suppliers and Price of 3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

There total 7 articles about 3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 847659-70-5
3',5'-di-O-acetyl-3-(2'-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one

: 319425-62-2
3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Guidance literature:: With ammonia; In methanol; at 22 ℃; for 20h;
DOI:10.1021/jo8007995

Reference yield: 71.0%

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 766-97-2
4-n-methylphenylacetylene

: 319425-62-2
3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 5h;
DOI:10.1016/j.bmc.2004.11.013

Reference yield:

: 766-97-2
4-n-methylphenylacetylene

: 319425-62-2
3-(2′-deoxy-β-D-ribofuranosyl)-6-(4-methylphenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4; CuI; DIPEA / dimethylformamide / 18 h / 20 °C

2: 131 mg / Et₃N; CuI / methanol / 4 h / Heating

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1081/NCN-100002299