methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate

Base Information

• Chemical Name: methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate
• CAS No.: 309248-36-0
• Molecular Formula: C₁₆H₁₈N₂O₇S
• Molecular Weight: 382.394
• Mol file: 309248-36-0.mol

Synonyms:methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate

Chemical Property of methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate

There total 1 articles about methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-allyl-o-nitrobenzenesulfonamide (65118-17-4) + meso-cyclopent-4-ene-1,3-diyl dimethyl dicarbonate → methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate (309248-36-0)

Guidance literature:

With [(1S,2S)-1,2-bis(2'-(Ph₂P)-benzamido)cyclohexane]2Pd; triethylamine; In tetrahydrofuran; at -60 - -35 ℃;

DOI:10.1021/ja001688i

Reference yield: 98.0%

methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate (309248-36-0) → 4-(N-nosyl-prop-2-enylamino)cyclopent-2-enol (309248-43-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1021/ja001688i

Reference yield:

methyl (1R,4S)-4-(N-nosyl-1-prop-2-enylamino)cyclopent-2-enyl carbonate (309248-36-0) → (1S,4S)-N,N'-dibenzyloxycarbonyl-N'-(4,4-diethoxybutyl)-N-prop-2-enyl-cyclopent-4-ene-1,3-diamine (309248-59-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaOH / dioxane / 1 h / 20 °C

2: 81 percent / PPh₃; DEAD / tetrahydrofuran / 1 h

3: K₂CO₃; thiophenol / dimethylformamide / 30 h / 70 °C

4: 135 mg / dimethylformamide / 0.17 h / 20 °C

With sodium hydroxide; potassium carbonate; thiophenol; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/ja001688i

upstream raw materials:

N-allyl-o-nitrobenzenesulfonamide

Downstream raw materials:

(1S,4R)-N'-(4,4-diethoxybutyl)-N,N'-dinosyl-N-prop-2-enylcyclopent-4-ene-1,3-diamine

4-(N-nosyl-prop-2-enylamino)cyclopent-2-enol

(1S,4S)-N,N'-dibenzyloxycarbonyl-N'-(4,4-diethoxybutyl)-N-prop-2-enyl-cyclopent-4-ene-1,3-diamine

(1S,4S)-N'-(4,4-diethoxybutyl)-N,N'-dinosyl-N-prop-2-enylcyclopent-4-ene-1,3-diamine