(R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate

Base Information

• Chemical Name: (R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate
• CAS No.: 1055312-46-3
• Molecular Formula: C₂₇H₃₁NO₈
• Molecular Weight: 497.545

Synonyms:(R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate

Chemical Property of (R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate

Chemical Property:

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Technology Process of (R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate

There total 1 articles about (R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-methyl 2-benzyloxymethyl-2-(4-methoxybenzylamino)-3-oxobutanoate (887776-07-0) + fumaric acid ethyl ester mono chloride (26367-48-6) → (R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate (1055312-46-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18.17h;

DOI:10.1016/j.tet.2008.06.038

Reference yield: 42.0%

(R)-ethyl (E)-3-[N-(1-benzyloxymethyl-1-carbomethoxy-2-oxopropyl)-N-(4-methoxybenzyl)carbamoyl]acrylate (1055312-46-3) → (3aS,6R,6aR)-6-benzyloxymethyl-5-(4-methoxybenzyl)-6a-methyl-2,4-dioxohexahydrofuro[2,3-c]pyrrole-6-carboxylic acid methyl ester (1055312-48-5) + (3aR,6R,6aS)-6-benzyloxymethyl-5-(4-methoxybenzyl)-6a-methyl-2,4-dioxohexahydrofuro[2,3-c]pyrrole-6-carboxylic acid methyl ester (1055312-47-4)

Guidance literature:

With diethylzinc; (Me₃P)2NiCl₂; In tetrahydrofuran; at -15 - 20 ℃; for 18h;

DOI:10.1016/j.tet.2008.06.038

upstream raw materials:

(R)-methyl 2-benzyloxymethyl-2-(4-methoxybenzylamino)-3-oxobutanoate

fumaric acid ethyl ester mono chloride

Downstream raw materials:

(3aS,6R,6aR)-6-benzyloxymethyl-5-(4-methoxybenzyl)-6a-methyl-2,4-dioxohexahydrofuro[2,3-c]pyrrole-6-carboxylic acid methyl ester

(3aR,6R,6aS)-6-benzyloxymethyl-5-(4-methoxybenzyl)-6a-methyl-2,4-dioxohexahydrofuro[2,3-c]pyrrole-6-carboxylic acid methyl ester

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