2--3-(2'-fluorobenzoyl)naphthalene

Base Information

Chemical Name:2--3-(2'-fluorobenzoyl)naphthalene
CAS No.:154849-03-3
Molecular Formula:C₁₉H₁₃BrFNO₂
Molecular Weight:386.22
Hs Code.:

2-<N-(bromoacetyl)amino>-3-(2'-fluorobenzoyl)naphthalene

Synonyms:2--3-(2'-fluorobenzoyl)naphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2--3-(2'-fluorobenzoyl)naphthalene

Chemical Property:

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Technology Process of 2--3-(2'-fluorobenzoyl)naphthalene

There total 4 articles about 2--3-(2'-fluorobenzoyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 598-21-0
2-Bromoacetyl bromide

: 153684-37-8
2-amino-1-(2'-fluorobenzoyl)naphthalene

: 154849-03-3
2--3-(2'-fluorobenzoyl)naphthalene

Guidance literature:: With sodium hydrogencarbonate; In chloroform; at 0 ℃; for 0.5h;
DOI:10.1021/jm00032a007

Reference yield:

: 153684-40-3,1026664-07-2
2-(2'-fluorobenzoyl)-3-(N-benzoylamino)naphthalene

: 154849-03-3
2--3-(2'-fluorobenzoyl)naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 48percent aq. HBr, glacial acetic acid / 10 h / Heating

2: 90 percent / NaHCO₃ / CHCl₃ / 0.5 h / 0 °C

With hydrogen bromide; sodium hydrogencarbonate; acetic acid; In chloroform;
DOI:10.1021/jm00032a007

Reference yield:

: 5959-52-4
2-Amino-3-naphthoic acid

: 154849-03-3
2--3-(2'-fluorobenzoyl)naphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / 3 h / 170 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 20 min

3: 97 percent / 48percent aq. HBr, glacial acetic acid / 10 h / Heating

4: 90 percent / NaHCO₃ / CHCl₃ / 0.5 h / 0 °C

With n-butyllithium; hydrogen bromide; sodium hydrogencarbonate; acetic acid; In chloroform;
DOI:10.1021/jm00032a007