3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid

Base Information

• Chemical Name: 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid
• CAS No.: 473543-61-2
• Molecular Formula: C₁₂H₈Cl₂N₂O₃
• Molecular Weight: 299.113
• Mol file: 473543-61-2.mol

Synonyms:3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid

Chemical Property of 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid

There total 4 articles about 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid ethyl ester (473543-60-1) → 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid (473543-61-2)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1021/ja027118v

Reference yield:

ethyl 5-methyl-1H-pyrrole-2-carboxylate (3284-51-3) → 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid (473543-61-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 72 percent / SO₂Cl₂

2.1: trimethylaluminium / hexane; CH₂Cl₂ / 0.5 h

2.2: 13 percent / hexane; CH₂Cl₂ / 72 h / Heating

3.1: 75 percent / aq. sodium hydroxide / ethanol / Heating

With sodium hydroxide; sulfuryl dichloride; trimethylaluminum; In ethanol; hexane; dichloromethane;

DOI:10.1021/ja027118v

Reference yield:

3,4-dichloro-1H-pyrrole-2,5-dicarboxylic acid diethyl ester (24728-04-9) → 3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid (473543-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylaluminium / hexane; CH₂Cl₂ / 0.5 h

1.2: 13 percent / hexane; CH₂Cl₂ / 72 h / Heating

2.1: 75 percent / aq. sodium hydroxide / ethanol / Heating

With sodium hydroxide; trimethylaluminum; In ethanol; hexane; dichloromethane;

DOI:10.1021/ja027118v

upstream raw materials:

3,4-dichloro-5-phenylcarbamoyl-1H-pyrrole-2-carboxylic acid ethyl ester

ethyl 5-methyl-1H-pyrrole-2-carboxylate

3,4-dichloro-1H-pyrrole-2,5-dicarboxylic acid diethyl ester

aniline