Technology Process of C16H22O4
There total 1 articles about C16H22O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: camphorsulfonic acid / dichloromethane / 2.5 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexane / -78 - 0 °C / Inert atmosphere
3: Jones reagent / acetone
4: diethyl ether / 1 h / 0 °C
With
Jones reagent; diisobutylaluminium hydride;
In
diethyl ether; hexane; dichloromethane; acetone;
3: |Jones Oxidation;
DOI:10.1002/anie.201203406
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ozone / dichloromethane / -78 °C
2.1: chromium dichloride / tetrahydrofuran / 2.33 h / 0 - 20 °C
3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / -78 - 20 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: water; methanesulfonamide; AD-mix-β / tert-butyl alcohol / 48 h / 0 °C
5.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / Inert atmosphere
6.1: diisobutylaluminium hydride / dichloromethane; hexane / -78 °C / Inert atmosphere
7.1: dichloromethane / 72 h / 55 °C
8.1: pyridine; dmap / dichloromethane / 24 h / 20 °C
With
pyridine; 1H-imidazole; chromium dichloride; dmap; methanesulfonamide; AD-mix-β; water; diisobutylaluminium hydride; ozone; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
2.1: |Takai-Utimoto Olefination / 3.2: |Suzuki-Miyaura Coupling / 7.1: |Wittig Olefination;
DOI:10.1002/anie.201203406
