1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

Base Information

Chemical Name:1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene
CAS No.:1373161-88-6
Molecular Formula:C₃₃H₃₃F
Molecular Weight:448.623
Hs Code.:

Synonyms:1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

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Chemical Property of 1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

Chemical Property:

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Technology Process of 1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

There total 4 articles about 1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-iodo-2-fluoro-3-cyclopropyl-4-(4-butylphenylethynyl)benzene

: 79887-09-5
(4-butylphenyl)acetylene

: 1373161-88-6
1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 60 ℃; for 16h;

Reference yield:

: 450412-29-0
1-bromo-3-fluoro-2-iodo-benzene

: 1373161-88-6
1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 85 °C

2.1: lithium hexamethyldisilazane; 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 1 h / -75 °C

2.2: 16 h / -20 °C

3.1: potassium tert-butylate; n-butyllithium / tetrahydrofuran / 0.5 h / -90 °C

3.2: 30 h / -90 °C

4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 16 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; copper(l) iodide; n-butyllithium; potassium tert-butylate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane;

Reference yield:

: 1-bromo-2-cyclopropyl-3-fluorobenzene

: 1373161-88-6
1-fluoro-2-cyclopropyl-3-(4-iH-butylphenylethynyl)-6-(4-iHbutyl-phenylethynyl)-benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane; 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 1 h / -75 °C

1.2: 16 h / -20 °C

2.1: potassium tert-butylate; n-butyllithium / tetrahydrofuran / 0.5 h / -90 °C

2.2: 30 h / -90 °C

3.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 16 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; potassium tert-butylate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;