(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

Base Information

Chemical Name:(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate
CAS No.:1262869-67-9
Molecular Formula:C₂HF₃O₂*C₂₄H₃₁N₃O
Molecular Weight:491.554
Hs Code.:

Synonyms:(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

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Chemical Property of (+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

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Technology Process of (+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

There total 10 articles about (+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1262870-25-6
(+)-3-benzyloxy-2-((2-dimethylaminophenyl(tert-butyloxylcarbonyl)amino)-N-benzyloxycarbonyl)morphinan

: 76-05-1
trifluoroacetic acid

: 1262869-67-9
(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

Guidance literature:: (+)-3-benzyloxy-2-((2-dimethylaminophenyl(tert-butyloxylcarbonyl)amino)-N-benzyloxycarbonyl)morphinan; With boron tribromide; In dichloromethane; at 0 ℃;

With methanol; In dichloromethane;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 15676-23-0
(+)-3-Hydroxymorphinan

: 1262869-67-9
(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1: nitric acid; formic acid / water / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C

4: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

5: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

6: dmap / tetrahydrofuran / 70 °C

7: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C

8: water; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

9: boron tribromide / dichloromethane / 0 °C

With dmap; formic acid; water; nitric acid; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262869-67-9
(+)-2-(2-(dimethylamino)phenylamino)-3-hydroxymorphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C

2: nitric acid; formic acid / water / 0 - 20 °C

3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

7: dmap / tetrahydrofuran / 70 °C

8: hydrazine hydrate / Raney nickel / methanol / 2 h / 20 °C

9: water; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

10: boron tribromide / dichloromethane / 0 °C

With dmap; formic acid; water; nitric acid; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;