N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine

Base Information

• Chemical Name: N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine
• CAS No.: 407618-18-2
• Molecular Formula: C₂₈H₂₆N₂O
• Molecular Weight: 406.527
• Mol file: 407618-18-2.mol

Synonyms:N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine

Chemical Property of N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine

There total 1 articles about N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Benzophenone imine (1013-88-3) + (2-bromophenyl)-(R)-2-methoxy-1-phenylethylamine (361979-02-4) → N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine (407618-18-2)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 135 ℃; for 0.0416667h;

DOI:10.1021/jo016251n

Reference yield: 92.0%

N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine (407618-18-2) → N-[(R)-2-methoxy-1-phenylethyl]-1,2-benzenediamine (407618-24-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo016251n

Reference yield:

N-[(R)-2-methoxy-1-phenylethyl]-N'-(diphenylmethylene)-1,2-benzenediamine (407618-18-2) → 1-[(R)-2-methoxy-1-phenylethyl]-1H-benzimidazole

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NH₂OH*HCl; NaOAc / methanol / 1 h / 20 °C

2: 90 percent / p-TsOH*H₂O / 8 h

With hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; In methanol;

DOI:10.1021/jo016251n

upstream raw materials:

Benzophenone imine

(2-bromophenyl)-(R)-2-methoxy-1-phenylethylamine

Downstream raw materials:

N-[(R)-2-methoxy-1-phenylethyl]-1,2-benzenediamine