Technology Process of (15R,19R)-tert-butyl 15-(benzyloxycarbonylamino)-19-(decylcarbamoyloxy)-14,22-dioxo-4,7,10,21-tetraoxa-17-thia-13, 23-diazatritriacontan-1-oate
There total 5 articles about (15R,19R)-tert-butyl 15-(benzyloxycarbonylamino)-19-(decylcarbamoyloxy)-14,22-dioxo-4,7,10,21-tetraoxa-17-thia-13, 23-diazatritriacontan-1-oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C
2.1: sodium hydroxide / tert-butyl alcohol / 0.5 h / 20 °C
2.2: 15 h / 20 °C
3.1: dmap / benzene / 40 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 4 h / 20 °C
With
dmap; 1,4-dithio-erythritol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
dichloromethane; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C
2.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C
3.1: sodium hydroxide / tert-butyl alcohol / 0.5 h / 20 °C
3.2: 15 h / 20 °C
4.1: dmap / benzene / 40 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 4 h / 20 °C
With
dmap; 1,4-dithio-erythritol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
dichloromethane; tert-butyl alcohol; benzene;
