2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

Base Information

Chemical Name:2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane
CAS No.:59555-86-1
Molecular Formula:C₁₅H₂₀O₄S
Molecular Weight:296.387
Hs Code.:

Synonyms:2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

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Chemical Property of 2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

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Technology Process of 2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

There total 5 articles about 2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 81583-16-6
Propionic acid (1R,2S)-1-methyl-2-(toluene-4-sulfonyl)-cyclopropylmethyl ester

: 59555-86-1
2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; 1.) -15 deg C, 0.3 h, 2.) room temperature, 0.5 h;
DOI:10.1021/jo00134a012

Reference yield:

: 59555-67-8
1-methyl-4-(3-methylbut-3-enylsulfonyl)benzene

: 59555-86-1
2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂

2: BuLi / hexane; tetrahydrofuran / 1.) -15 deg C, 0.5 h, 2.) room temperature, 0.3 h

3: pyridine

4: 85 percent / BuLi / tetrahydrofuran / 1.) -15 deg C, 0.3 h, 2.) room temperature, 0.5 h

With pyridine; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo00134a012

Reference yield:

: 59555-71-4
1,2-epoxy-2-methyl-4-(p-tolylsulfonyl)butane

: 59555-86-1
2-ethyl-2-hydroxy-5-methyl-1-(p-tolylsulfonyl)-3-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 3 steps

1: BuLi / hexane; tetrahydrofuran / 1.) -15 deg C, 0.5 h, 2.) room temperature, 0.3 h

2: pyridine

3: 85 percent / BuLi / tetrahydrofuran / 1.) -15 deg C, 0.3 h, 2.) room temperature, 0.5 h

With pyridine; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/jo00134a012