4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

Base Information

Chemical Name:4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester
CAS No.:881894-72-0
Molecular Formula:C₂₆H₃₉F₃N₂O₇
Molecular Weight:548.6
Hs Code.:

Synonyms:4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

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Chemical Property of 4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

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Technology Process of 4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

There total 6 articles about 4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 881894-71-9
4,6-Diamino-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

: 407-25-0
trifluoroacetic anhydride

: 881894-72-0
4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

Guidance literature:: With triethylamine; In dichloromethane; for 7h;
DOI:10.1021/ol0526322

Reference yield:

: 881894-70-8
4,6-Dinitro-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

: 881894-72-0
4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 6 h / 20 °C

2: 68 percent / Et₃N / CH₂Cl₂ / 7 h

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ol0526322

Reference yield:

: 89-87-2,156617-89-9,37551-97-6
2,4-dimethylnitrobenzene

: 881894-72-0
4-Amino-6-(2,2,2-trifluoro-acetylamino)-isophthalic acid bis-[(S)-2-(3-methyl-butoxy)-propyl] ester

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / HNO₃; H₂SO₄ / H₂O / 1 h

2: 70 percent / CrO₃; H₂SO₄ / 10 - 20 °C

3: SOCl₂ / Heating

4: Et₃N / CH₂Cl₂ / 5 h / 20 °C

5: 92 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 6 h / 20 °C

6: 68 percent / Et₃N / CH₂Cl₂ / 7 h

With chromium(VI) oxide; thionyl chloride; sulfuric acid; hydrogen; nitric acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/ol0526322